For determining the Correlation between lung cancer patients who have undergone lobectomy and have a mental illness, the team developed multiple machine learning models. For this study, we split the data into 80% training data (4464 sample data) and 20% test data (1117 sample data).

We divided this problem statement into two areas of evaluation:

• Predicting LOS of a patient with both lung cancer and mental illness using only Diagnosis codes.
• Predicting LOS of a patient with both lung cancer and mental illness using both Diagnosis codes and Socio-demographic features.

The following algorithms were then developed:

• SGDRegressor
• GradientBoostingRegressor
• LinearRegression
• KNeighborsRegressor
• RandomForestRegressor
• SVR
• TensorFlow

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DATA DISTRIBUTION

For any machine learning algorithm to be designed, it is important to understand the variability of the data and skewness, as well as the assumptions that we can make to build machine learning models. Here are some key statistical distribution models of the dataset we used for our study:

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During the course of our study, we specifically focused on lung cancer patients who have undergone lobectomy (lung cancer surgery) and analyze if any specific mental illness/psychiatric diagnoses or groups of diagnoses increase perioperative death risk.

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Lung cancer is the number one cause of cancer-related deaths worldwide. Patients with severe mental illness (SMI) are a group who are overrepresented in the lung cancer population. SMI refers to psychological problems, including mood disorders, major depression, schizophrenia, bipolar disorder, and substance abuse disorders, that inhibit a person’s ability to engage in functional and occupational activities.

Cancer patients diagnosed with SMI may not adhere to treatment plans and may have reduced access to healthcare. Individuals with SMI may have advanced tumor growth at diagnosis due to factors such as limited access to healthcare and healthcare systems. The aggregation of inadequate healthcare and increased risk for somatic disorders in patients with SMI can explain higher mortality rates. Many research papers have indicated that cancer represents a significant proportion of excess mortality for people with mental illness. Mental illness is typically associated with suicide, but much of the excess mortality rates associated with mental illness are due to cardiovascular or respiratory diseases and cancer. (more…)